Ricombinante Anti-OCT-2 Anticorpo [OCT2/7073R] (A278047)

Anti-OCT-2 Antibody [OCT2/7073R]

Recombinant rabbit monoclonal [OCT2/7073R] antibody to OCT-2.

Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. Oct-2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of Oct-2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of Oct-2. Several studies of Oct-2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for Oct-2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 112-297, of human OCT-2 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

OCT2/7073R

IgG

Unconjugated

Protein A/G chromatography.

200 µg/ml

60 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-OCT-2 Antibody [OCT2/7073R] - BSA and Azide free (A278635).

class 2, Lymphoid restricted immunoglobulin octamer binding protein, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, NF A2, Oct 2, Octamer binding transcription factor 2, Octamer-binding protein 2, Octamer-binding transcription factor 2, OTF-2, OTF2, PO2F2_HUMAN, POU domain, POU domain class 2 transcription factor 2, POU2F2, transcription factor 2