Recombinant Anti-Nucleophosmin Antibody [NPM1/7072R] (A278038)

Anti-Nucleophosmin Antibody [NPM1/7072R]

Recombinant rabbit monoclonal [NPM1/7072R] antibody to Nucleophosmin.

This antibody recognizes a 33kDa glycoprotein, identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm.It is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location.Mutations in this gene are associated with acute myeloid leukemia.The antibody may be a useful aid for classification of acute myeloid leukemia.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment corresponding to human Nucleophosmin. The exact sequence is proprietary.

Rabbit

Monoclonal

NPM1/7072R

IgG

Protein A/G chromatography.

200 µg/ml

33 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Nucleophosmin Antibody [NPM1/7072R] - BSA and Azide free (A278626).

NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin