Anti-Notch2 Anticorpo [HMN2-35] (A280635)

Anti-Notch2 Antibody [HMN2-35]

Hamster monoclonal [HMN2-35] antibody to Notch2.

This antibody recognises Notch 2, one of the four major transmembrane receptors (Notch 1-4) of the Notch signaling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands. Signaling through Notch 2 has been implicated in the development of marginal zone B cells (MZB), the sensitization of endothelial cells to apoptosis, and the regulation of the expression of CD23 in B-cell lymphocytic leukemia (B-CLL). There is a negative correlation between Notch 2 expression and the grade of human breast cancer.Hamster anti Mouse Notch 2 antibody, clone HMN2-35 cross-reacts with rat mast cell line RBL-2H3 and Y3 myeloma cells, in flow cytometry.

Flow Cytometry

Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Mouse, Rat

Mouse Notch 2-Fc fusion protein.

Hamster

Monoclonal

HMN2-35

IgG

Protein G affinity chromatography of tissue culture supernatant.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Hamster anti Mouse Notch 2 antibody, clone HMN2-35 recognizes Notch 2, one of the four major transmembrane receptors (Notch 1-4) of the Notch signaling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands. Signaling through Notch 2 has been implicated in the development of marginal zone B cells (MZB), the sensitization of endothelial cells to apoptosis, and the regulation of the expression of CD23 in B-cell lymphocytic leukemia (B-CLL). There is a negative correlation between Notch 2 expression and the grade of human breast cancer.Hamster anti Mouse Notch 2 antibody, clone HMN2-35 cross-reacts with rat mast cell line RBL-2H3 and Y3 myeloma cells, in flow cytometry.

AGS2, hN2, Motch B, N2, N2ECD, N2ICD, neurogenic locus notch homolog protein 2, NOTC2_HUMAN, Notch 2, Notch 2 intracellular domain, Notch Drosophila homolog 2, Notch homolog 2, Notch homolog 2 Drosophila