Anti-NCR1 Anticorpo [VIV-KM1] (PE) (A320259)

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Anti-NCR1 Anticorpo [VIV-KM1] (PE) (A320259) è stato interrotto e non è più disponibile.

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Nome
Anti-NCR1 Antibody [VIV-KM1] (PE)
Descrizione
Mouse monoclonal [VIV-KM1] antibody to NCR1 (PE).
Specificità
This antibody recognises the porcine homologue of human CD335, also known as NKp46 and natural cytotoxicity triggering receptor 1 (NCR1), a member of the natural cytotoxicity receptor (NCR) family.CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor and is involved in the control of viral infection and tumor development. CD335 is expressed by human natural killer cells. The development of monoclonal antibodies to bovine CD335 (clone AKS1) and ovine CD335 (clone EC1.1) have enabled researchers to identify and better understand ruminant NK cells. Mouse anti Pig CD335 antibody, clone VIV-KM is the first monoclonal developed to specifically identify porcine CD335 and provides a reagent to facilitate a better understanding of the pig immune system and aid in the understanding of the role of NK cells in host pathogen defense. Porcine CD335 is not expressed by all NK cells and expression may be influenced by cytokine production.
Applicazioni
Flow Cytometry
Diluizioni consigliate
Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 106 cells in 100µl
Reattività
Porcine
Immunogeno
Fusion protein consisting of the extracellular region of porcine CD335.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
VIV-KM1
Isotipo
IgG1
Coniugare

PE

Excitation: 565nm, Emission: 578nm

Purificazione
Protein A affinity chromatography of tissue culture supernatant.
Concentrazione
Reconstitution dependent.
Forma del prodotto
Lyophilized
Ricostituzione
Reconstitute with 1 ml of distilled water.
Formulazione
Supplied in Phosphate Buffered Saline with 1% BSA, 5% Sucrose, and 0.09% Sodium Azide.
Conservazione
Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Note generali
Mouse anti Pig CD335 antibody, clone VIV-KM1 recognizes the porcine homologue of human CD335, also known as NKp46 and natural cytotoxicity triggering receptor 1 (NCR1), a member of the natural cytotoxicity receptor (NCR) family.CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor and is involved in the control of viral infection and tumor development. CD335 is expressed by human natural killer cells (Sivori et al.1997). The development of monoclonal antibodies to bovine CD335 (clone AKS1) (Storset et al. 2004) and ovine CD335 (clone EC1.1) (Connelley et al.2011) have enabled researchers to identify and better understand ruminant NK cells.Mouse anti Pig CD335 antibody, clone VIV-KM is the first monoclonal developed to specifically identify porcine CD335 and provides a reagent to facilitate a better understanding of the pig immune system and aid in the understanding of the role of NK cells in host pathogen defense. Porcine CD335 is not expressed by all NK cells and expression may be influenced by cytokine production (Mair et al. 2012).
Sinonimi
Activating NK receptor NK p46, CD335, FLJ99094, hNKp46, Ly94, Lymphocyte antigen 94, Lymphocyte antigen 94 homolog, Lymphocyte antigen 94 homolog (activating NK receptor; NK p46), Natural cytotoxicity triggering receptor 1, Natural killer cell p46-related protein, NCT1, NCTR1_HUMAN, NK cell activating receptor, NK cell-activating receptor, NK-p46, NKp46
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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