Anti-NADPH Oxidase 4 Antibody [NOX4/1245] - BSA and Azide free
Descrizione
Mouse monoclonal [NOX4/1245] antibody to NADPH Oxidase 4.
Specificità
The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome, cytochrome b558, to form the active enzyme complex. The p22 and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. NOX4 is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. It is also expressed in fetal tissues, placenta, glioblastoma and vascular cells.
Applicazioni
ELISA
Diluizioni consigliate
WB: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant human NOX4 protein.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
NOX4/1245
Isotipo
IgG2b
Catene leggere
kappa
Coniugare
Unconjugated
Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
70 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
SDS-PAGE analysis of Anti-NADPH Oxidase 4 Antibody [NOX4/1245] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
Prodotti alternativi a Anti-NADPH Oxidase 4 Anticorpo [NOX4/1245] (A252734)