Ricombinante Anti-MUM1 Anticorpo [MUM1/8274R] (A315343)

Anti-MUM1 Antibody [MUM1/8274R]

Recombinant rabbit monoclonal [MUM1/8274R] antibody to MUM1.

MUM1 is one of nuclear transcription factors necessary for development and activation of B lymphocytes. MUM1 belongs to the IRF gene family containing at least 10 widely expressed genes with similar DNA binding motif all involved in regulation of cell growth, transformation and induction of apoptosis as well as development of T-cell immune response. The synonym of MUM1 is Interferon Regulatory Factor 4 (IRF4). MUM1 is found mainly in B-cell lymphoma and melanocytic lesions. Significant variation in positivity mainly due to chromosomal translocations involving MUM1 gene among T-cell lymphomas is observed. MUM1 is useful in a panel with other markers for subclassification of malignant lymphomas and identification of plasma cell differentiation. Particularly MUM1 may be useful for the identification of plasma cell differentiation when morphologic evidence is lacking and Ig light chains are difficult to interpret.

IHC-P

Human tonsil or diffuse large B-cell lymphoma (DLBCL).

IHC: 1-2 µg/ml

Human

Recombinant fragment (corresponding to C-terminal) of IRF4 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

MUM1/8274R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

52 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Interferon regulatory factor 4, IRF 4, IRF-4, Irf4, IRF4_HUMAN, LSIRF, Lymphocyte specific interferon regulatory factor, Lymphocyte specific IRF, Lymphocyte-specific interferon regulatory factor, Multiple myeloma oncogene 1, MUM 1, NF EM5, NF-EM5, NFEM5, PU.1 interaction partner, Sfpi1/PU.1 interaction partner, Transcriptional activator PIP