Ricombinante Anti-Mucin 5AC Anticorpo [MUC5AC/7068R] (A278621)

Anticorpo monoclonale [MUC5AC/7068R] di coniglio contro Mucin 5AC per IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-Mucin 5AC Antibody [MUC5AC/7068R] - BSA and Azide free
Descrizione
Recombinant rabbit monoclonal [MUC5AC/7068R] antibody to Mucin 5AC.
Specificità
Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 6 carries GlcNAcα1 4Galβ R structures, indicating that α1, 4-Nacetylglucosaminyltransferase is important to the formation of the mucous glycoproteins in vivo. Mucin 5AC is a gel-forming mucin that is secreted from surface mucous cells. Glucocorticoid is required for the expression of Mucin 5AC mRNA and high doses of hydrocortisone suppresses its expression. Additionally, asthmatic fluid stimulates Mucin 5AC synthesis several-fold. The pro-inflammatory cytokines IL-6 and TNFα stimulate Mucin 5AC secretion and thus contribute to the upregulation of mucin by chronic inflammation. Expression of Mucin 5AC is retinoic acid (RA)- or retinol-dependent, and RA control of mucin genes is mediated by the retinoid acid receptor RARα and, to a lesser extent, by RARγ. Thyroid hormone binding to thyroid receptors inhibits Mucin 5AC gene expression. Mucin 5AC is also expressed in normal endocervical epithelium, small intestine, gastric cells (Lewis type 1) and gastric metaplasia and it is one of the major mucins in the ethmoid mucosa.
Applicazioni
IHC-P
Diluizioni consigliate
IHC-P: 1-2 µg/ml
Reattività
Human
Reattività incrociata
This antibody is predicted to cross react with Monkey, Rabbit, Feline, Mouse, Rat, Bovine, and Chicken.
Immunogeno
Recombinant full-length human MUC5AC protein.
Specie ospite
Rabbit
Clonalità
Monoclonal
Clona ID
MUC5AC/7068R
Isotipo
IgG
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
>1,000 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Note generali
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Mucin 5AC Antibody [MUC5AC/7068R] (A278033).
Sinonimi
Apomucin, Apomucin Major Airway Glycoprotein, Gastric mucin, LeB, Lewis B blood group antigen, Major Airway Glycoprotein, MUC 5, MUC5, MUC5AC, Mucin, Mucin 5 subtype AC tracheobronchial, Mucin 5 Subtypes A And C, Mucin 5 subtypes A and C tracheobronchial/gastric, Mucin 5, tracheobronchial/gastric, Mucin 5AC oligomeric mucus/gel forming, Mucin 5AC, oligomeric mucus/gel forming pseudogene, TBM, Tracheobronchial mucin, Tracheobronchial Mucin (TBM)
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

Prodotti alternativi a Anti-Mucin 5AC Anticorpo [MUC5AC/7068R] (A278621)

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