Ricombinante Anti-MSH6 Anticorpo [rMSH6/8181] (A316720)

$765

Anticorpo monoclonale [rMSH6/8181] di topo contro MSH6 per IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-MSH6 Antibody [rMSH6/8181] - BSA and Azide free
Descrizione
Recombinant mouse monoclonal [rMSH6/8181] antibody to MSH6.
Specificità
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
Applicazioni
IHC-P
Controllo positivo
Human colon carcinoma (IHC).
Diluizioni consigliate
IHC: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant fragment of human MSH6 protein (around Amino Acids 300-600). The exact sequence is proprietary.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
rMSH6/8181
Isotipo
IgG1
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
163 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sinonimi
DNA mismatch repair protein Msh6, G/T mismatch binding protein, G/T mismatch-binding protein, GTBP, GTMBP, hMSH6, HNPCC 5, HNPCC5, HSAP, MSH 6, MSH6_HUMAN, mutS (E. coli) homolog 6, MutS alpha 160 kDa subunit, mutS homolog 6, MutS homolog 6 (E. coli), MutS-alpha 160 kDa subunit, p160, Sperm associated protein
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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