Anti-MSH6 Anticorpo [MSH6/3085] (A248784)

Nome
Anti-MSH6 Antibody [MSH6/3085]
Descrizione
Mouse monoclonal [MSH6/3085] antibody to MSH6.
Specificità
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
Applicazioni
ELISA, IF, WB, IHC-P
Diluizioni consigliate
IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant fragment, around amino acids 374-540, of human MSH6 protein. The exact sequence is proprietary.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
MSH6/3085
Isotipo
IgG2b
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
200 µg/ml
Peso molecolare
85 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Note generali
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MSH6 Antibody [MSH6/3085] - BSA and Azide free (A251964).
Sinonimi
DNA mismatch repair protein Msh6, G/T mismatch binding protein, G/T mismatch-binding protein, GTBP, GTMBP, hMSH6, HNPCC 5, HNPCC5, HSAP, MSH 6, MSH6_HUMAN, mutS (E. coli) homolog 6, MutS alpha 160 kDa subunit, mutS homolog 6, MutS homolog 6 (E. coli), MutS-alpha 160 kDa subunit, p160, Sperm associated protein
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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