MR1 (major histocompatibility complex, class I-related), also known as HLALS, is a 341 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum, as well as to the extracellular side of the cell membrane, and contains one Ig-like C1-type domain. Expressed ubiquitously, MR1 exists as a heterodimer with b-2-Microglobulin and plays an important role in antigen presentation, specifically in the development and expansion of mucosalassociated invariant T cells (MAITs). MAITs are located in the gut and are involved in monitoring flora levels, as well as in conveying distress signals to other areas of the body, indicating a role for MR1 in proper digestion and immune system function. MR1 exists as four alternatively spliced isoforms and is encoded by a gene which maps to human chromosome 1.

Applicazioni

IHC-P

Controllo positivo

Human kidney, placenta or tonsil.

Diluizioni consigliate

IHC: 1-2 µg/ml

Reattività

Human

Immunogeno

Recombinant fragment (around Amino Acids 50-250) of human MR1 protein. The exact sequence is proprietary.

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

MR1/7577

Isotipo

IgG2

Catene leggere

kappa

Coniugare

Unconjugated

Purificazione

Protein A/G chromatography.

Concentrazione

200 µg/ml

Peso molecolare

39 kDa

Forma del prodotto

Liquid

Formulazione

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conservazione

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Sinonimi

Class I histocompatibility antigen like protein, Class I histocompatibility antigen-like protein, HLALS, HMR1_HUMAN, Major histocompatibility complex class I like sequence, Major histocompatibility complex class I related, Major histocompatibility complex class I related gene protein, Major histocompatibility complex class I related isoform CRA a, Major histocompatibility complex class I related isoform CRA c, Major histocompatibility complex class I related isoform CRA d, Major histocompatibility complex class I-related gene protein, MHC class I like antigen MR 1, MHC class I like antigen MR1, MHC class I related gene protein, MHC class I related protein 1 isoform B, MHC class I related protein 1 isoform C, MHC class I-related gene protein, MR 1, Mr1 protein, MR1B, MR1C

Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.