Anti-MerTK Anticorpo [MERTK/3024] (A278119)

Name: Anti-MerTK Antibody [MERTK/3024] - BSA and Azide free
Brand: Antibodies.com
SKU: A278119
Price: 525.0 USD
Availability: InStock

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$525

Anticorpo monoclonale [MERTK/3024] di topo contro MerTK per IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Consegna

Spese di spedizione

$40

Tempi di consegna

4-6 Giorni lavorativi

Contattaci

Telefono

+1 (314) 370-6046

E-mail

orders@antibodies.com

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Garanzia di qualità al 100%

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Tag dei prodotti:

Anticorpo Monospecifico

Descrizione Prodotto

Nome

Anti-MerTK Antibody [MERTK/3024] - BSA and Azide free

Descrizione

Mouse monoclonal [MERTK/3024] antibody to MerTK.

Specificità

MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C Î³2 (PI-PLC Î³2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.

Applicazioni

IHC-P

Diluizioni consigliate

IHC-P: 1-2 µg/ml

Reattività

Human

Immunogeno

Recombinant fragment, around amino acids 5-148, of human MerTK. The exact sequence is proprietary.

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

MERTK/3024

Isotipo

IgG2a

Coniugare

Unconjugated

Purificazione

Protein A/G chromatography.

Concentrazione

1 mg/ml

Peso molecolare

110 kDa

Forma del prodotto

Liquid

Formulazione

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Conservazione

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Note generali

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-MerTK Antibody [MERTK/3024] (A277531).

Sinonimi

c MER, c mer proto oncogene tyrosine kinase, c-mer, cMER, cmer protooncogene tyrosine kinase, Eyk, MER, MER receptor tyrosine kinase, MERK, MERPEN, MERTK c-mer proto-oncogene tyrosine kinase, MERTK_HUMAN, MGC133349, nmf12, Nyk, Proto oncogene tyrosine protein kinase MER, Proto oncogene tyrosine protein kinase MER precursor, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, RP38, STK kinase, Tyrosine-protein kinase Mer

Controlli isotipo

Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

Immagini (3)

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Figure 1: Immunohistochemistry - Anti-MerTK Antibody [MERTK/3024] - BSA and Azide free (A278119)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma tissue using Anti-MerTK Antibody [MERTK/3024].

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Figure 2: Immunohistochemistry - Anti-MerTK Antibody [MERTK/3024] - BSA and Azide free (A278119)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma tissue using Anti-MerTK Antibody [MERTK/3024].

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Figure 3: Anti-MerTK Antibody [MERTK/3024] - BSA and Azide free (A278119)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-MerTK Antibody [MERTK/3024]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.