Anti-MEF2D Anticorpo [PCRP-MEF2D-3A4] (A277705)

Anti-MEF2D Antibody [PCRP-MEF2D-3A4]

Mouse monoclonal [PCRP-MEF2D-3A4] antibody to MEF2D.

The myocyte enhancer factor-2 (MEF-2) family of transcription factors associate with co-repessors or co-activators to regulate development and function of T cells, neuronal cells and muscle cells. Four family members arise from alternatively spliced transcripts, termed MEF-2A, -2B, -2C and -2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each duing embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5 and MRF4, are one class of identified factors. A second family of DNA-binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF-2) family. Each of these proteins binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes.

IP, Flow Cytometry, IF, IHC-P

IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human

This antibody is predicted to cross react with Mouse and Rat.

Recombinant full-length human MEF2D protein.

Mouse

Monoclonal

PCRP-MEF2D-3A4

Unconjugated

Protein A/G chromatography.

200 µg/ml

55.94 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MEF2D Antibody [PCRP-MEF2D-3A4] - BSA and Azide free (A278293).

DKFZp686I1536, MADS box transcription factor 2 polypeptide D, MEF2D_HUMAN, Myocyte enhancer factor 2D, Myocyte specific enhancer factor 2, polypeptide D, Myocyte specific enhancer factor 2D, Myocyte-specific enhancer factor 2D