Anti-MCP2 Anticorpo [E09-8A1] (Biotin) (A280293)

Anti-MCP2 Antibody [E09-8A1] (Biotin)

Mouse monoclonal [E09-8A1] antibody to MCP2 (Biotin).

This antibody recognises C-C motif chemokine-8 (CCL8) also known as HC14, monocyte chemoattractant protein 2, monocytes chemotactic protein 2 and small-inducible cytokine A8. CCL8 is a member of the C-C chemokine subfamily and is an agonist for C-C chemokine receptor type 2 and CCR5. Through these receptors, CCL8 is involved in the immune response by attracting monocytes, T-lymphocytes, natural killer cells, basophils, mast cells and eosinophils. Proteolytic cleavage of CCL8 to CCL8 (6-76) converts the chemokine into a potent inhibitor of C-C chemokine-induced chemotaxis. The biotinylated Mouse anti Human CCL8 antibody, clone E09-8A1 (MCA6267B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL8 antibody, clone E07-8G5 (MCA6266GA) as the capture antibody.

ELISA

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CCL8 (Gln24-Pro99).

Mouse

Monoclonal

E09-8A1

IgG2a

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CCL8 antibody, clone E09-8A1, recognizes C-C motif chemokine-8 (CCL8) also known as HC14, monocyte chemoattractant protein 2, monocytes chemotactic protein 2 and small-inducible cytokine A8. CCL8 is a member of the C-C chemokine subfamily and is an agonist for C-C chemokine receptor type 2 and CCR5 (Ge et al. 2017). Through these receptors, CCL8 is involved in the immune response by attracting monocytes, T-lymphocytes, natural killer cells, basophils, mast cells and eosinophils (Farmaki et al. 2020). Proteolytic cleavage of CCL8 to CCL8 (6-76) converts the chemokine into a potent inhibitor of C-C chemokine-induced chemotaxis (Proost et al. 1998).The biotinylated Mouse anti Human CCL8 antibody, clone E09-8A1 (MCA6267B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL8 antibody, clone E07-8G5 (MCA6266GA) as the capture antibody.

C C motif chemokine 8, CCL 8, Ccl8, CCL8_HUMAN, Chemokine (C C motif) ligand 8, Chemokine ligand 8, HC14, MCP 2, MCP-2, MCP-2(6-76), Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2, SCYA10, SCYA8, Small inducible cytokine A8, Small inducible cytokine subfamily A (Cys Cys) member 8, Small-inducible cytokine A8

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.