Recombinant Anti-MCM3 Antibody [MCM3/8972R] (A315289)

Anti-MCM3 Antibody [MCM3/8972R]

Recombinant rabbit monoclonal [MCM3/8972R] antibody to MCM3.

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

MCF-7, Jurkat or Ramos cells. Human colon or tonsil.

IHC: 1-2 µg/ml

Human

Recombinant fragment (aa 650-750) of human MCM3 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

MCM3/8972R

kappa

Protein A/G chromatography.

200 µg/ml

115 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

DNA polymerase alpha holoenzyme-associated protein P1, DNA replication licensing factor MCM3, P1-MCM3, p102, RLF subunit beta