Anti-Major Vault Proteina Anticorpo [SPM280] (A253996)

Anticorpo monoclonale [SPM280] di topo contro Major Vault Protein per Flow Cytometry, IF e IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-Major Vault Protein Antibody [SPM280] - BSA and Azide free
Descrizione
Mouse monoclonal [SPM280] antibody to Major Vault Protein.
Specificità
This antibody recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for 70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
Applicazioni
Flow Cytometry, IF, IHC-P
Diluizioni consigliate
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reattività
Human
Immunogeno
Proteins precipitated from human breast cancer MCF-7 cells.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
SPM280
Isotipo
IgG1
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
104-110 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Note generali
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Major Vault Protein Antibody [SPM280] (A250816).
Sinonimi
LRP, Lung resistance related protein, Lung resistance-related protein, Major vault protein, rat, homolog of, MVP, MVP_HUMAN, testicular secretory protein Li 30, VAULT 1, VAULT1
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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