Mouse monoclonal [1014] antibody to Major Vault Protein.
Specificità
This antibody recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for 70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
LRP, Lung resistance related protein, Lung resistance-related protein, Major vault protein, rat, homolog of, MVP, MVP_HUMAN, testicular secretory protein Li 30, VAULT 1, VAULT1
Figure 2: Immunofluorescence - Anti-Major Vault Protein Antibody [1014] (A250814)
Immunofluorescent analysis of A549 cells stained with Anti-Major Vault Protein Antibody [1014] followed by Goat Anti-Mouse IgG (CF® 488) (Green). The nuclear counterstain is RedDot (Red).
Figure 3: SDS-PAGE - Anti-Major Vault Protein Antibody [1014] (A250814)
SDS-PAGE analysis of Anti-Major Vault Protein Antibody [1014] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
Prodotti alternativi a Anti-Major Vault Proteina Anticorpo [1014] (A250814)