Anti-LAMP1 Anticorpo [LAMP1/7458] (A315234)

Anti-LAMP1 Antibody [LAMP1/7458]

Mouse monoclonal [LAMP1/7458] antibody to LAMP1.

Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107a) and LAMP-2 (also designated CD107b) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans-Golgi network and are transported intracellularly via a pathway that is distinct from the Clathrincoated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of Thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.

IHC-P

Human tonsil, placenta, kidney or prostate.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 200-400) of human LAMP1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

LAMP1/7458

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

120 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CD107 antigen like family member A, CD107 antigen-like family member A, CD107a, CD107a antigen, LAMP 1, LAMP-1, LAMP1_HUMAN, LAMPA, LGP120, lgpA, Lysosomal Associated Membrane Protein 1, Lysosomal membrane glycoprotein 120KD, Lysosome associated membrane glycoprotein 1, Lysosome-associated membrane glycoprotein 1, Lysosome-associated membrane protein 1, OTTHUMP00000040663