Anti-Ku80 Antibody [XRCC5/7313] (A315223)

Anti-Ku80 Antibody [XRCC5/7313]

Mouse monoclonal [XRCC5/7313] antibody to Ku80.

The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Ku has several functions, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity; serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters.

Human thyroid or lymph node.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 300-500) of human XRCC5. The exact sequence is proprietary.

Mouse

Monoclonal

IgG2c

kappa

Protein A/G chromatography.

200 µg/ml

80-86 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.