Anti-Kallikrein 5 Anticorpo [KLK5/3844] (A316582)

$765

Anticorpo monoclonale [KLK5/3844] di topo contro Kallikrein 5 per IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-Kallikrein 5 Antibody [KLK5/3844] - BSA and Azide free
Descrizione
Mouse monoclonal [KLK5/3844] antibody to Kallikrein 5.
Specificità
Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK5 expression is abundant in skin, mammary gland and testis.
Applicazioni
IHC-P
Controllo positivo
Human skin tissue (IHC). MCF-7 cell lysates.
Diluizioni consigliate
IHC: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant fragment of human KLK5 protein (around Amino Acids 36-177). The exact sequence is proprietary.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
KLK5/3844
Isotipo
IgG2b
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
33 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sinonimi
HK5, Kallikrein L2, Kallikrein like 2, Kallikrein like protein 2, Kallikrein related peptidase 5, Kallikrein-5, Kallikrein-like protein 2, Kallikrein5, KLK 5, KLK L2, KLK-L2, KLK5, KLK5_HUMAN, KLKL 2, KLKL2, SCTE, Stratum corneum tryptic enzyme, UNQ570/PRO1132
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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