Rabbit polyclonal antibody to IRS1 (phospho Ser312).
Specificità
This antibody recognises insulin receptor substrate 1 (IRS1), when phosphorylated at serine 312. IRS proteins are substrates of the insulin receptor tyrosine kinase and play a key role in insulin signaling.IRS1 is phosphorylated at serine 312 by MAPK8/JNK1 and IKK, inhibiting insulin signaling.
Applicazioni
WB
Diluizioni consigliate
WB: 1:500 - 1:2,000
Reattività
Human, Mouse, Rat
Immunogeno
Phospho-specific peptide corresponding to residues surrounding Ser312 of human IRS1.
Specie ospite
Rabbit
Clonalità
Polyclonal
Isotipo
IgG
Coniugare
Unconjugated
Concentrazione
Lot Specific
Forma del prodotto
Liquid
Formulazione
Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.
Conservazione
Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
Note generali
Rabbit anti IRS1 (pSer312) antibody recognizes insulin receptor substrate 1 (IRS1), when phosphorylated at serine 312. IRS proteins are substrates of the insulin receptor tyrosine kinase and play a key role in insulin signaling.IRS1 is phosphorylated at serine 312 by MAPK8/JNK1 and IKK, inhibiting insulin signaling (Zhang et al. 2008).
