Anti-IRF3 Anticorpo [PCRP-IRF3-1D11] (A277679)

Anti-IRF3 Antibody [PCRP-IRF3-1D11]

Mouse monoclonal [PCRP-IRF3-1D11] antibody to IRF3.

Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-αand β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-αand interferon-βgenes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3γp48 and IFN consensus sequence-binding protein (ICSBP).

IF, WB

IF: 1-2 µg/ml, WB: 1-2 µg/ml

Human

Recombinant full-length human IRF3 protein.

Mouse

Monoclonal

PCRP-IRF3-1D11

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

50 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-IRF3 Antibody [PCRP-IRF3-1D11] - BSA and Azide free (A278267).

IIAE7, Interferon regulatory factor 3, IRF 3, IRF-3, IRF3_HUMAN, MGC94729