This antibody recognises human Interleukin-1 receptor-associated kinase 3 (IRAK3), a member of the IRAK/Pelle family. IRAKs associate with the IL1/Toll receptors after IL-1 or LPS stimulation, thereby playing an important role in the inflammatory response.IRAK3 inhibits the dissociation of IRAK1 and IRAK4 from the Toll-like receptor signalling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilising the receptor complex. It is predominantly expressed in peripheral blood lymphocytes. Defects in the IRAK3 gene are associated with susceptibility to asthma-related traits type 5.Rabbit anti Human IRAK3 antibody does not cross-react with IRAK or IRAK2.

Applicazioni

WB, IHC-P

Diluizioni consigliate

IHC-P 1: 2 µg/ml, WB: 0.5 - 1 µg/ml

Reattività

Human, Mouse, Rat

Immunogeno

A peptide corresponding to amino acids from the C-terminus of human IRAK3.

Specie ospite

Rabbit

Clonalità

Polyclonal

Isotipo

IgG

Coniugare

Unconjugated

Concentrazione

1 mg/ml

Peso molecolare

Approximately 68 kDa in mouse spleen lysates.

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

Rabbit anti Human IRAK3 antibody recognizes human Interleukin-1 receptor-associated kinase 3 (IRAK3), a member of the IRAK/Pelle family. IRAKs associate with the IL1/Toll receptors after IL-1 or LPS stimulation, thereby playing an important role in the inflammatory response.IRAK3 inhibits the dissociation of IRAK1 and IRAK4 from the Toll-like receptor signalling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilising the receptor complex. It is predominantly expressed in peripheral blood lymphocytes. Defects in the IRAK3 gene are associated with susceptibility to asthma-related traits type 5.Rabbit anti Human IRAK3 antibody does not cross-react with IRAK or IRAK2.

Sinonimi

ASRT5, IL 1 receptor associated kinase M, IL-1 receptor-associated kinase M, IL1 receptor associated kinase M, Interleukin 1 receptor associated kinase 3, Interleukin 1 receptor associated kinase M, Interleukin-1 receptor-associated kinase 3, IRAK M, IRAK-3, IRAK-M, Irak3, IRAK3_HUMAN

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Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.