Anti-Interferon alpha Antibody - BSA and Azide free (A283972)

Anti-Interferon alpha Antibody - BSA and Azide free

Rabbit polyclonal antibody to Interferon alpha.

This antibody recognises chicken Interferon alpha (chIFNa). Similarities exist between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes , chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and acts as a potent antiviral agent. Rabbit anti Chicken interferon alpha antibody (AHP943Z) cross reacts with IFN beta in western blots but does not show any cross reactivity with IFN gamma and in bioassays, Rabbit anti Chicken interferon alpha antibody neutralizes chIFN-alpha, but not chIFN-beta, and can therefore be used to discriminate IFN alpha and IFN beta bioactivities.

ELISA, Functional Assays, WB, IP

Chicken

Recombinant Chicken IFN alpha

Rabbit

Polyclonal

IgG

500 µg/ml

Liquid

Supplied in Phosphate Buffered Saline.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti Chicken interferon alpha antibody recognizes chicken Interferon alpha (chIFNa). Similarities exist between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes (Sick et al. 1996), chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and acts as a potent antiviral agent (Schwartz et al. 2004).Rabbit anti Chicken interferon alpha antibody (AHP943Z) cross reacts with IFN beta in western blots but does not show any cross reactivity with IFN gamma and in bioassays, Rabbit anti Chicken interferon alpha antibody neutralizes chIFN-alpha, but not chIFN-beta, and can therefore be used to discriminate IFN alpha and IFN beta bioactivities (Schwartz et al. 2004).

IFN-alpha-1/13, IFNA1, Interferon alpha-1/13, Interferon alpha-D, LeIF D