Ricombinante Anti-IL-7 Anticorpo [IL7/7053R] (A278595)

Anti-IL-7 Antibody [IL7/7053R] - BSA and Azide free

Recombinant rabbit monoclonal [IL7/7053R] antibody to IL-7.

Interleukin-7 (IL-7) was originally described as a factor capable of inducing in vitro proliferation of pre-B cells from marrow cultures. The IL-7 gene encodes a protein 177 amino acids in length. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor specific chain and the IL-2 receptor γ chain common to the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors. IL-7 stimulation leads to the activation of Janus tyrosine kinase family members JAK1 and JAK3. Other studies have shown that in T cells, the IL-7 receptor-specific chain associates with the Src kinases family Lck and Fyn. IL-7 induces phosphorylation of Insulin receptor substrate-1 (IRS-1) and Insulin receptor substrate-2 (IRS-2), originally called 4PS.

Flow Cytometry, IF

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 27-177, corresponding to mature human IL-7. The exact sequence is proprietary.

Rabbit

Monoclonal

IL7/7053R

IgG

Protein A/G chromatography.

1 mg/ml

25 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-IL-7 Antibody [IL7/7053R] (A278007).

IL 7, IL7, IL7 nirs variant 6, IL7_HUMAN, Interleukin 7, Interleukin-7, Interleukin7, LP-1, Lymphopoietin 1