This antibody recognises human IL-32, a 26 kDa cytokine. There are four known isoforms of IL-32, IL-32a, ß d and ?. IL-32 activates NF-kappa-B and p38 MAPK cytokine signaling pathways. IL-32 has a pro-inflammatory role in innate and adaptive immune responses and is produced by mitogen-activated lymphocytes, IFN gamma-activated epithelial cells and IL-12, IL-18, IL-32-activated NK cells. IL-32 is expressed at elevated levels after the activation of T-cells by mitogens or the activation of NK cells by IL-2. Among its other effects in innate immunity are the induction of the crucial inflammatory cytokines TNFa and IL-6. and it shows elevated levels of expression in various inflammatory autoimmune diseases, certain cancers, as well as viral infections (Kim, 2014).

Applicazioni

WB, ELISA

Diluizioni consigliate

WB: 1:1,000

Reattività

Human

Immunogeno

E. coli derived recombinant protein corresponding to amino acids 2-131 of human IL-32 alpha.

Sequenza

CFPKVLSDDMKKLKARMVMLLPTSAQGLGAWVSACDTEDTVGHLGPWRDKDPALWCQLCLSSQHQAIERFYDKMQNAESGRGQVMSSLAELEDDFKEGYLETVAAYYEEQHPELTPLLEKERDGLRCRGN

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

B08-3A9

Isotipo

IgG1

Coniugare

Unconjugated

Purificazione

Protein G affinity chromatography of ascites.

Concentrazione

1 mg/ml

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

Mouse anti Human Interleukin-32, clone B08-3A9, recognizes human IL-32, a 26 kDa cytokine. There are four known isoforms of IL-32, IL-32a, ß d and ?. IL-32 activates NF-kappa-B and p38 MAPK cytokine signaling pathways. IL-32 has a pro-inflammatory role in innate and adaptive immune responses and is produced by mitogen-activated lymphocytes, IFN gamma-activated epithelial cells and IL-12, IL-18, IL-32-activated NK cells. IL-32 is expressed at elevated levels after the activation of T-cells by mitogens or the activation of NK cells by IL-2. Among its other effects in innate immunity are the induction of the crucial inflammatory cytokines TNFa and IL-6. and it shows elevated levels of expression in various inflammatory autoimmune diseases, certain cancers, as well as viral infections (Kim, 2014).

Sinonimi

IL 32alpha, IL 32beta, IL 32delta, IL 32gamma, IL32, IL32_HUMAN, Interleukin 32, Interleukin 32 small, Interleukin 32 theta, Interleukin-32, interleukin-32 eta, Natural killer cell transcript 4, Natural killer cells protein 4, NK 4, NK4, OTTHUMP00000236040, OTTHUMP00000236041, OTTHUMP00000236042, OTTHUMP00000236043, OTTHUMP00000236044, OTTHUMP00000236045, OTTHUMP00000236046, OTTHUMP00000236047, OTTHUMP00000236048, OTTHUMP00000236049, OTTHUMP00000236050, OTTHUMP00000236051, OTTHUMP00000236052, OTTHUMP00000236053, OTTHUMP00000236054, OTTHUMP00000241545, OTTHUMP00000241602, OTTHUMP00000241603, OTTHUMP00000241604, OTTHUMP00000241605, OTTHUMP00000241606, OTTHUMP00000241607, OTTHUMP00000241608, OTTHUMP00000241609, OTTHUMP00000241610, OTTHUMP00000241611, OTTHUMP00000241612, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, Tumor necrosis factor alpha-inducing factor

Controlli isotipo

Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.