Anti-IL-3 Antibody [IL3/4003] - BSA and Azide free (A316560)

Anti-IL-3 Antibody [IL3/4003] - BSA and Azide free

Mouse monoclonal [IL3/4003] antibody to IL-3.

Interleukin-3, or IL-3, is a pleiotropic cytokine that is primarily secreted by activated T lymphocytes and stimulates the proliferation and differentiation of hematopoietic cells. IL-3 not only supports growth of both pluripotent stem cells and the more differentiated committed progenitors, but it also stimulates the functional activity of some fully differentiated cells. IL-3 has also been shown to protect mast cells from undergoing apoptosis. IL-3 exerts its biological effects through a receptor which consists of a ligand-specific subunit has been shown to be necessary for activation of the MAP kinase signaling pathway. Although the IL-3 receptor has no intrinsic kinase activity, stimulation with IL-3 leads to tyrosine phosphorylation of the JAK/Tyk 2 family member, JAK2, which in turn activates and causes nuclear translocation of Stat5a and Stat5b.

Human thymus or tonsil tissue.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human IL3 protein. The exact sequence is proprietary.

Mouse

Monoclonal

IL3/4003

kappa

Protein A/G chromatography.

1 mg/ml

17 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Hematopoietic growth factor, IL3, Interleukin-3, Mast cell growth factor, MCGF, Multipotential colony-stimulating factor, P-cell-stimulating factor