Anti-IL-3 Antibody [5A4-1-16] - BSA and Azide free (A279418)

Anti-IL-3 Antibody [5A4-1-16] - BSA and Azide free

Mouse monoclonal [5A4-1-16] antibody to IL-3.

This antibody recognises interleukin-3 (IL-3) also known as hematopeietic growth factor, mast cell growth factor, multi potential colony-stimulating factor and p-cell-stimulatory factor. IL-3 is a member of the ß common cytokine family which is expressed by both hematopoietic and non-hematopoeitic cells. T cells are a major expresser of IL-3 during inflammation as a result of allergic reactions, parasitic and viral infection. Upon binding to its receptor IL3-Ra, the JAK and STAT signaling pathways can be activated. This is used to activate plasmacytoid dendritic cells during viral infection and the expansion of mast cells and basophils during parasitic infection.

WB, ELISA

ELISA: 8.0 µg/ml - 4.0 µg/ml, WB: 0.25 µg/ml - 0.5 µg/ml

Human

E. coli derived recombinant human interleukin-3.

Mouse

Monoclonal

5A4-1-16

IgG1

Protein G affinity chromatography of tissue culture supernatant.

Lyophilized

Reconstitute with 0.5 ml of distilled water.

Supplied in Phosphate Buffered Saline.

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human interleukin-3 antibody, clone 5A4-1-16, recognizes interleukin-3 (IL-3) also known as hematopeietic growth factor, mast cell growth factor, multi potential colony-stimulating factor and p-cell-stimulatory factor. IL-3 is a member of the ß common cytokine family which is expressed by both hematopoietic and non-hematopoeitic cells. T cells are a major expresser of IL-3 during inflammation as a result of allergic reactions, parasitic and viral infection (Borriello et al. 2019). Upon binding to its receptor IL3-Ra, the JAK and STAT signaling pathways can be activated. This is used to activate plasmacytoid dendritic cells during viral infection and the expansion of mast cells and basophils during parasitic infection (Dougan et al. 2019).

Hematopoietic growth factor, IL3, Interleukin-3, Mast cell growth factor, MCGF, Multipotential colony-stimulating factor, P-cell-stimulating factor