Anti-IL-17A Anticorpo (A283861)

Anti-IL-17A Antibody - BSA and Azide free

Rabbit polyclonal antibody to IL-17A.

This antibody recognises human IL-17 (Interleukin-17/17A), also known as Cytotoxic T-lymphocyte-associated antigen 8 or CTLA-8. Interleukin-17 is a homodimer of two 132 amino acid chains resulting oin a ~32 kDa disulfide-linked cytokine belonging to the IL-17 family (classified as IL-17A to IL-17F) which signals through the IL-17 receptor (IL-17R/CDw217).IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNF-a, IFN-?, and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. IL-17 has roles in bone metabolism and rheumatoid arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.

IF, WB, ELISA, IHC-P, Functional Assays

ELISA: 0.5 - 2 µg/ml, Functional Assays 1: 0.93 - 1.3 µg/ml, IHC-P 2: 0.25 µg/ml, WB: 0.1 - 0.2 µg/ml

Human

Recombinant human IL-17.

Rabbit

Polyclonal

IgG

Unconjugated

Lyophilized

Reconstitute with 0.1 ml of distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Gently mix after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended. For functional studies do not add sodium azide

Supplied in Phosphate Buffered Saline.

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti Human Interleukin-17 antibody recognizes human IL-17 (Interleukin-17/17A), also known as Cytotoxic T-lymphocyte-associated antigen 8 or CTLA-8. Interleukin-17 is a homodimer of two 132 amino acid chains resulting oin a ~32 kDa disulfide-linked cytokine belonging to the IL-17 family (classified as IL-17A to IL-17F) which signals through the IL-17 receptor (IL-17R/CDw217).IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNF-a, IFN-?, and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. IL-17 has roles in bone metabolism and rheumatoid arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction (Ziolkowska et al. 2000).

CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL17, Il17a, IL17_HUMAN, Interleukin-17A