Ricombinante Anti-IL-1 beta Anticorpo [IL1B/7049R] (A278004)

Anti-IL-1 beta Antibody [IL1B/7049R]

Recombinant rabbit monoclonal [IL1B/7049R] antibody to IL-1 beta.

This antibody recognizes a protein of 17-31kDa, identified as interleukin 1beta. It shows no cross-reaction with interleukin 1alpha. Epitopes of MAb IL1B/463 and IL1B/7049R are different and provide a good pair for developing an ELISA. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment corresponding to human IL-1 beta. The exact sequence is proprietary.

Rabbit

Monoclonal

IL1B/7049R

IgG

Protein A/G chromatography.

200 µg/ml

31 kDa (proprotein) / 17 kDa (mature)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-IL-1 beta Antibody [IL1B/7049R] - BSA and Azide free (A278592).

Catabolin, H1, Hematopoietin 1 , IFN beta inducing factor , IL 1 , IL 1 beta , IL 1B, IL 1beta, IL1 , IL1 beta, IL1B, IL1B_HUMAN, IL1F2 , Interleukin 1 beta , Interleukin 1 beta precursor , Interleukin-1 beta, LAF, OAF, Osteoclast activating factor , OTTHUMP00000162031, Preinterleukin 1 beta, Preinterleukin beta , Pro interleukin 1 beta