Anti-IL-1 beta Anticorpo [IL1B/4649] (A315144)

Anti-IL-1 beta Antibody [IL1B/4649]

Mouse monoclonal [IL1B/4649] antibody to IL-1 beta.

Recognizes a protein of 17-31kDa, identified as interleukin 1beta. It shows no cross-reaction with interleukin 1alpha. Epitopes of MAb IL1B/463 and IL1B/4649 are different and provide a good pair for developing an ELISA. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

ELISA, IHC-P

LPS stimulated human peripheral blood mononuclear cells. Human adrenal gland, colon or liver tissue.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 100-269) of human IL1B protein. The exact sequence is proprietary.

Mouse

Monoclonal

IL1B/4649

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

31 kDa (proprotein) / 17 kDa (mature)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Catabolin, H1, Hematopoietin 1 , IFN beta inducing factor , IL 1 , IL 1 beta , IL 1B, IL 1beta, IL1 , IL1 beta, IL1B, IL1B_HUMAN, IL1F2 , Interleukin 1 beta , Interleukin 1 beta precursor , Interleukin-1 beta, LAF, OAF, Osteoclast activating factor , OTTHUMP00000162031, Preinterleukin 1 beta, Preinterleukin beta , Pro interleukin 1 beta