Ricombinante Anti-HLA DR Anticorpo [HLA-DRA/8286R] (A315095)

Anti-HLA DR Antibody [HLA-DRA/8286R]

Recombinant rabbit monoclonal [HLA-DRA/8286R] antibody to HLA DR.

This MAb reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. s respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.

IHC

Human tonsil or lymph node.

IHC: (Frozen & Formalin-fixed) 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human HLA-DR protein. The exact sequence is proprietary.

Rabbit

Monoclonal

HLA-DRA/8286R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

~28 kDa (beta chain)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

HLA DP, HLA DR + HLA DP, MHC Class II