Ricombinante Anti-HLA Class II DRB1 Anticorpo [rHLA-DRB/7198] (A315087)

Anti-HLA Class II DRB1 Antibody [rHLA-DRB/7198]

Recombinant mouse monoclonal [rHLA-DRB/7198] antibody to HLA Class II DRB1.

This MAb reacts with a 28kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. s respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.

IHC-P

Raji, Ramos, Daudi or HuT78 cells. Human lymphoid tissue.

IHC: 1-2 µg/ml

Human

Recombinant full-length human HLA-DRB1 protein.

Mouse

Monoclonal

rHLA-DRB/7198

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

28 kDa (beta chain)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

2B1F_HUMAN, DR1, DR16, DR5, DR8, DRB1, DRw10, DW2.2/DR2.2, FLJ75017, FLJ76359, HLA class II antigen beta chain, HLA class II histocompatibility antigen, DR-1 beta chain, HLA class II histocompatibility antigen, DRB1-15 beta chain, HLA-DR-beta 1, HLA-DR1B, HLA-DRB, HLA-DRB1, human leucocyte antigen DRB1, Leucocyte antigen DR beta 1 chain, leucocyte antigen DRB1, lymphocyte antigen DRB1, major histocompatibility complex, class II, DR beta 1, MHC class II antigen, MHC class II antigen DRB1*15, MHC class II antigen HLA-DR13, MHC class II HLA-DR beta 1 chain, MHC class II HLA-DR-beta cell surface glycoprotein, MHC class II HLA-DRw10-beta, SS1