Anti-HDAC7 Anticorpo [PCRP-HDAC7-1B6] (A315070)

Anti-HDAC7 Antibody [PCRP-HDAC7-1B6]

Mouse monoclonal [PCRP-HDAC7-1B6] antibody to HDAC7.

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC7 is a histone deacetylase that interacts with the adaptor mSin3A. The interaction of HDAC7 with mSin3A suggests the association of multiple repression complexes of transcription factors.

Flow Cytometry

HeLa cells.

Flow Cytometry: 1-2 µg/million cells

Human

Recombinant full-length human HDAC7 protein.

Mouse

Monoclonal

IgG

Unconjugated

Protein A/G chromatography.

200 µg/ml

105 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

DKFZP586J0917, FLJ99588, HD 7a, HD7, HD7a, HDAC 7, HDAC 7A, HDAC7A, HDAC7_HUMAN, Histone deacetylase 7, Histone deacetylase 7A, OTTHUMP00000202813, OTTHUMP00000202814