Anti-GP2 Anticorpo [GP2/3510] (A315044)

Anti-GP2 Antibody [GP2/3510]

Mouse monoclonal [GP2/3510] antibody to GP2.

GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.

ELISA, WB, IHC-P

PANC-1 cells. Human pancreas.

ELISA: 2-4 µg/ml for coating, WB: 1-2 µg/ml, IHC: 1-2 µg/ml

Human

Recombinant fragment of human GP2 protein (around Amino Acids 35-179). The exact sequence is proprietary.

Mouse

Monoclonal

IgG2c

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

Predicted 59 kDa / Observed 100 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

GCTM-2 antigen, Gp200, MGC138240, PC, PCLP, PCLP-1, PCLP1, Pcx, Podocalyxin, Podocalyxin like, Podocalyxin like protein, Podocalyxin-like protein 1, PODXL, PODXL_HUMAN