Anti-FOXO1A Anticorpo (A283410)

Anti-FOXO1A Antibody

Rabbit polyclonal antibody to FOXO1A.

This antibody recognises Forkhead box protein O1, also known as FOXO1, Forkhead box protein O1A or Forkhead in rhabdomyosarcoma.FOXO1 like other members of the forkhead protein family acts as a transcription factor by binding to DNA with its forkhead box protein domain. The subcellular activation and thereby the transcriptional activity of FOXO1 is regulated via AKT mediated phosphorylation while its levels are regulated via polyubiquitination.FOXO1 has been shown to play a role in various signaling pathways ranging from apoptosis, proliferation, oxidative stress, DNA damage to insulin signaling. The protein has also been proposed to act as a tumor suppressor (Fu and Tindall 2008, Xie et al.2012).

WB

WB: 1:100 - 1:1,000

Human, Rat

Synthetic peptide corresponding to amino acids 633-647 of human FOXO1.

DNVLPNQSFPHSVKT

Rabbit

Polyclonal

IgG

Unconjugated

Approximately 66 kDa in HeLa cell lysate, 293T cell lysate and rat heart tissue lysate

Liquid

Supplied in Phosphate Buffered Saline with 1 mg/ml BSA and <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti FOXO1 antibody recognizes Forkhead box protein O1, also known as FOXO1, Forkhead box protein O1A or Forkhead in rhabdomyosarcoma.FOXO1 like other members of the forkhead protein family acts as a transcription factor by binding to DNA with its forkhead box protein domain. The subcellular activation and thereby the transcriptional activity of FOXO1 is regulated via AKT mediated phosphorylation while its levels are regulated via polyubiquitination.FOXO1 has been shown to play a role in various signaling pathways ranging from apoptosis, proliferation, oxidative stress, DNA damage to insulin signaling (Huang and Tindall 2007). The protein has also been proposed to act as a tumor suppressor (Fu and Tindall 2008, Xie et al.2012).

FKH 1, FKH1, FKHR, Forkhead (Drosophila) homolog 1 (rhabdomyosarcoma), Forkhead box O1, Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, Forkhead, Drosophila, homolog of, in rhabdomyosarcoma, FoxO transcription factor, foxo1, FOXO1_HUMAN, OTTHUMP00000018301