Ricombinante Anti-Ferritin Heavy Chain Anticorpo [FTH/8700R] (A314953)

$765

Anticorpo monoclonale [FTH/8700R] di coniglio contro Ferritin Heavy Chain per IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-Ferritin Heavy Chain Antibody [FTH/8700R]
Descrizione
Recombinant rabbit monoclonal [FTH/8700R] antibody to Ferritin Heavy Chain.
Specificità
Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidationof FeI(II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed; and oxidative stress, an important factor in the development of aging-related cataracts.
Applicazioni
IHC-P
Controllo positivo
Human liver tissue. Liver tissue lysate.
Diluizioni consigliate
IHC: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant human FTH1 protein fragment (around Amino Acids 58-180). The exact sequence is proprietary.
Specie ospite
Rabbit
Clonalità
Monoclonal
Clona ID
FTH/8700R
Isotipo
IgG
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
200 µg/ml
Peso molecolare
21 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sinonimi
Apoferritin, Cell proliferation inducing gene 15 protein, Cell proliferation-inducing gene 15 protein, F HC, Ferritin H subunit, Ferritin heavy polypeptide 1, FHC, FRIH, FRIH_HUMAN, FTH, FTH 1, FTH1, FTH1 protein, FTHL 6, FTHL6, Iron overload autosomal dominant, MGC104426, N-terminally processed, OK/SW-cl.84, PIG 15, PIG15, Placenta immunoregulatory factor, PLIF, Proliferation inducing gene 15 protein, Proliferation inducing protein 15
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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