Anti-FAT1 Anticorpo [FAT1-3D7/1] (A248527)

Anticorpo monoclonale [FAT1-3D7/1] di topo contro FAT1 per ELISA, WB e IF.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-FAT1 Antibody [FAT1-3D7/1]
Descrizione
Mouse monoclonal [FAT1-3D7/1] antibody to FAT1.
Specificità
The FAT proteins are members of the Cadherin superfamily homologous to the Drosophila Fat protein that functions as a positive regulator of planar cell polarity in the Drosophila wing. FAT1 is an unusual cadherin that controls cell growth and planar polarity while acting as a tumor suppressor. FAT1 is a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin-dependent cell motility. FAT1 is localized at the leading edge of lamellipodia, filopodia and microspike tips where it directly interacts with Ena/VASP proteins to regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, the cytoplasmic domain of FAT1 recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. FAT1 expression in vascular smooth muscle cells (VSMCs) increases significantly after arterial injury or growth factor stimulation, implicating FAT1 in the control of VSMC functions central to vascular remodeling by facilitating migration and limiting proliferation. FAT1 is also involved in psychic disorders, and its action may be of patho-physiological importance.
Applicazioni
ELISA, WB, IF
Diluizioni consigliate
WB: 1-2 µg/ml, IF: 1-2 µg/ml
Reattività
Drosophila melanogaster
Reattività incrociata
This antibody is predicted to cross-react with Chimpanzee and Rat due to sequence homology; 92% and 85% identity, respectively.
Immunogeno
Cytoplasmic domain of drosophila FAT protein.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
FAT1-3D7/1
Isotipo
IgM
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
200 µg/ml
Peso molecolare
500 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Note generali
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-FAT1 Antibody [FAT1-3D7/1] - BSA and Azide free (A254301).
Sinonimi
Cadherin family member 7, Cadherin family member 7 precursor, Cadherin ME5, Cadherin related tumor suppressor, Cadherin related tumor suppressor homolog, Cadherin related tumor suppressor homolog precursor, Cadherin related tumor suppressor homolog precursor (FAT protein homolog), Cadherin-related tumor suppressor homolog, CDHF 7, CDHF7, FAT, FAT 1, FAT tumor suppressor 1, FAT tumor suppressor homolog 1, FAT1_HUMAN, hFAT, hFat 1, hFat1, Homolog of Drosophila FAT protein, Homolog of Drosophila FAT protein precursor, Homolog of Drosophila tumor suppressor FAT precursor, ME 5, ME5, nuclear form, Protein fat homolog, Protocadherin Fat 1
Controlli isotipo
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

Prodotti alternativi a Anti-FAT1 Anticorpo [FAT1-3D7/1] (A248527)

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