Anti-Fas Anticorpo [FAS/3112] (A249020)

Name: Anti-Fas Antibody [FAS/3112]
Brand: Antibodies.com
SKU: A249020
Price: 525.0 USD
Availability: InStock

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$525

Anticorpo monoclonale [FAS/3112] di topo contro Fas per ELISA e IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Consegna

Spese di spedizione

$40

Tempi di consegna

4-6 Giorni lavorativi

Contattaci

Telefono

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanzie

Garanzia di qualità al 100%

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Tag dei prodotti:

Anticorpo Monospecifico Plasma Membrane Marker

Descrizione Prodotto

Nome

Anti-Fas Antibody [FAS/3112]

Descrizione

Mouse monoclonal [FAS/3112] antibody to Fas.

Specificità

This antibody specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycoside-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.

Applicazioni

ELISA, IHC-P

Diluizioni consigliate

IHC-P: 1-2 µg/ml

Reattività

Human

Immunogeno

Recombinant fragment, around amino acids 26-96, of human CD95 protein. The exact sequence is proprietary.

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

FAS/3112

Isotipo

IgG2b

Catene leggere

kappa

Coniugare

Unconjugated

Purificazione

Protein A/G chromatography.

Concentrazione

200 µg/ml

Peso molecolare

38-50 kDa

Forma del prodotto

Liquid

Formulazione

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conservazione

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Note generali

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Fas Antibody [FAS/3112] - BSA and Azide free (A252200).

Sinonimi

ALPS 1A, ALPS1A, APO 1, Apo 1 antigen, APO 1 cell surface antigen, Apo-1 antigen, APO1, Apo1 antigen, APO1 cell surface antigen, Apoptosis antigen 1, Apoptosis mediating surface antigen FAS, Apoptosis-mediating surface antigen FAS, APT 1, APT1, CD 95, CD 95 antigen, CD95, CD95 antigen , Delta Fas, Delta Fas/APO 1/CD95, Delta Fas/APO1/CD95, Fas (TNF receptor superfamily, member 6), FAS 1, FAS 827dupA, Fas AMA, FAS Antigen, Fas cell surface death receptor, FAS1, FASLG receptor, FASTM, sFAS, Surface antigen APO1, TNF receptor superfamily, member 6, TNFRSF 6, TNFRSF6, TNR6_HUMAN, Tumor necrosis factor receptor superfamily member 6

Controlli isotipo

Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

Immagini (4)

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Figure 1: Immunohistochemistry - Anti-Fas Antibody [FAS/3112] (A249020)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon using Anti-Fas Antibody [FAS/3112].

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Figure 2: Immunohistochemistry - Anti-Fas Antibody [FAS/3112] (A249020)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon using Anti-Fas Antibody [FAS/3112].

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Figure 3: SDS-PAGE - Anti-Fas Antibody [FAS/3112] (A249020)

SDS-PAGE analysis of Anti-Fas Antibody [FAS/3112] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 4: Anti-Fas Antibody [FAS/3112] (A249020)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-Fas Antibody [FAS/3112]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.