Anti-ERCC1 Antibody [ERCC1/7596] (A314922)

Anti-ERCC1 Antibody [ERCC1/7596]

Mouse monoclonal [ERCC1/7596] antibody to ERCC1.

Recognizes a protein of 110kDa, identified as Excision Repair Cross Complementing 1 (ERCC1). It is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.

HeLa or HepG2 cells. Tonsil or Prostate.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 191-281) of human ERCC1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

ERCC1/7596

kappa

Protein A/G chromatography.

200 µg/ml

110 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

DNA excision repair protein ERCC-1