This antibody recognises human Tumor necrosis factor receptor superfamily member 21, also known as death domain containing receptor DR6, Death receptor 6 or CD358. DR6 is a 655 amino acid ~72 kDa type 1 single pass transmembrane glycoprotein with four extracellular cysteine rich repeats and a single cytoplasmic death domain. DR6 is widely expressed in human tissues and cell lines. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK.

Applicazioni

Diluizioni consigliate

WB: 1:500

Reattività

Human

Immunogeno

A peptide corresponding to amino acids 42-56 of human DR6 precursor.

Sequenza

QPEQKASNLIGTYRH

Specie ospite

Rabbit

Clonalità

Polyclonal

Isotipo

IgG

Coniugare

Unconjugated

Concentrazione

500 µg/ml

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Conservazione

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Note generali

Rabbit anti Human DR6 antibody recognizes human Tumor necrosis factor receptor superfamily member 21, also known as death domain containing receptor DR6, Death receptor 6 or CD358. DR6 is a 655 amino acid ~72 kDa type 1 single pass transmembrane glycoprotein with four extracellular cysteine rich repeats and a single cytoplasmic death domain. DR6 is widely expressed in human tissues and cell lines. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK (Pan et al. 1998).

Sinonimi

BM 018, BM018, CD358, Death receptor 6, DR 6, MGC31965, OTTHUMP00000039915, TNFR related death receptor 6, TNFRSF 21, TNFRSF21, TNFRSF21 protein, TNR21_HUMAN, Tumor necrosis factor receptor superfamily member 21, Tumor necrosis factor receptor superfamily member 21 precursor

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Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.