Anti-Desmin Anticorpo [DES/4526] (A314885)

Anti-Desmin Antibody [DES/4526]

Mouse monoclonal [DES/4526] antibody to Desmin.

Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

IHC-P

SJRH30 cells. Human uterus, small intestine or leiomyosarcoma.

IHC: 1-2 µg/ml

Human

Recombinant full-length human desmin protein.

Mouse

Monoclonal

DES/4526

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

52 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CMD1I, CSM1, CSM2, DES, DESM_HUMAN, FLJ12025, FLJ39719, FLJ41013, FLJ41793, Intermediate filament protein, OTTHUMP00000064865