Ricombinante Anti-Decorin Anticorpo [DCN/7031R] (A277970)

Anti-Decorin Antibody [DCN/7031R]

Recombinant rabbit monoclonal [DCN/7031R] antibody to Decorin.

Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFβ and is a direct or indirect negative modulator of TGFβ synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-γ and TNFα may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 212-336, of human Decorin. The exact sequence is proprietary.

Rabbit

Monoclonal

DCN/7031R

IgG

Protein A/G chromatography.

200 µg/ml

43 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Decorin Antibody [DCN/7031R] - BSA and Azide free (A278558).

Bone proteoglycan II, CSCD, DCN, DCN protein, Decorin proteoglycan, Dermatan sulphate proteoglycans II, DKFZp686J19238, DSPG 2, DSPG2, PG 40, PG II, PG S2, PG-S2, PG40, PGII, PGS 2, PGS2, PGS2_HUMAN, Proteoglycan core protein, SLRR1B, Small leucine rich protein 1B