This antibody recognises the amino Terminal of human DcR3, otherwise known as Decoy Receptor 3, a ~33 kDa member of the tumour necrosis factor receptor superfamily. DcR3 acts as a receptor for FasL and LIGHT, preventing them from binding to their cell death receptors and thereby inhibiting apoptosis. DcR3 is a soluble decoy receptor found in adult stomach, spinal cord, lymph node, trachea, spleen and lung. It may also be found in fetal lung, brain and liver and is highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Applicazioni

WB, IHC-P

Diluizioni consigliate

IHC-P 1: 1 µg/ml, WB: 0.5 - 1 µg/ml

Reattività

Human, Mouse, Rat

Immunogeno

A peptide corresponding to amino acids near the N-terminus of human DcR3 precursor.

Specie ospite

Rabbit

Clonalità

Polyclonal

Isotipo

IgG

Coniugare

Unconjugated

Concentrazione

500 µg/ml

Peso molecolare

Approximately 33 kDa in human heart lysate.

Forma del prodotto

Liquid

Formulazione

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

Rabbit anti Human DcR3 (N-Terminal) antibody recognizes the amino Terminal of human DcR3, otherwise known as Decoy Receptor 3, a ~33 kDa member of the tumour necrosis factor receptor superfamily. DcR3 acts as a receptor for FasL and LIGHT, preventing them from binding to their cell death receptors and thereby inhibiting apoptosis. DcR3 is a soluble decoy receptor found in adult stomach, spinal cord, lymph node, trachea, spleen and lung. It may also be found in fetal lung, brain and liver and is highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Sinonimi

Decoy receptor 3, Decoy receptor for Fas ligand, DJ583P15.1.1, M68, M68E, OTTHUMP00000031583, TNF6B_HUMAN, TNFRSF6B, TR6, Tumor necrosis factor receptor superfamily member 6B, Tumor necrosis factor receptor superfamily member 6b decoy, UNQ186/PRO212

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Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.