This antibody recognises human Deleted in azoospermia-like, also known as DAZL, DAZ homolog, DAZ-like autosomal, Deleted in azoospermia-like 1 or SPGY-like-autosomal. DAZL is a 295 amino acid ~33 kDa member of the DAZ (deleted in azoospermia) family of RNA binding proteins. DAZL is expressed in fetal and adult testes and ovaries, and is believed to play a role in germ cell development. In adult germ cells, the expression of DAZL is predominantly localized to the cytoplasm.Mutations in this gene have been linked to severe spermatogenic failure and infertility in males

Applicazioni

WB, IHC-P, IF

Reattività

Human, Mouse, Rat, Cynomolgus monkey

Immunogeno

Synthetic peptide sequence CRVHHFRRSRAMLKSV from within the C-terminus of human DAZL.

Sequenza

CRVHHFRRSRAMLKSV

Specie ospite

Mouse

Clonalità

Monoclonal

Clona ID

3/11A

Isotipo

IgG1

Coniugare

Unconjugated

Concentrazione

Lot Specific

Purezza

Tissue Culture Supernatant containing 0.1M Tris/HCl

Forma del prodotto

Liquid

Formulazione

Supplied in <0.1% Sodium Azide.

Conservazione

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Note generali

Mouse anti Human DAZL antibody, clone 3/11A recognizes human Deleted in azoospermia-like, also known as DAZL, DAZ homolog, DAZ-like autosomal, Deleted in azoospermia-like 1 or SPGY-like-autosomal. DAZL is a 295 amino acid ~33 kDa member of the DAZ (deleted in azoospermia) family of RNA binding proteins. DAZL is expressed in fetal and adult testes and ovaries, and is believed to play a role in germ cell development. In adult germ cells, the expression of DAZL is predominantly localized to the cytoplasm.Mutations in this gene have been linked to severe spermatogenic failure and infertility in males (Lin et al. 2001)

Sinonimi

DAZ homolog, DAZ like autosomal, DAZ-like autosomal, DAZH, DAZL 1, DAZL1, DAZLA, DAZL_HUMAN, Deleted in azoospermia like, Deleted in azoospermia like 1, Deleted in azoospermia like autosomal, Deleted in azoospermia-like, Deleted in azoospermia-like 1, Germline specific RNA binding protein, MGC26406, Spermatogenesis gene on the Y like autosomal, SPGY like autosomal, SPGY-like-autosomal, SPGYLA, Tpx2

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Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.