Ricombinante Anti-Cytokeratin 17 Anticorpo [KRT17/8346R] (A314859)

Anti-Cytokeratin 17 Antibody [KRT17/8346R]

Recombinant rabbit monoclonal [KRT17/8346R] antibody to Cytokeratin 17.

CK17 is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glandssuch as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. Additionally, anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.

IHC-P

T24 cells. Human skin, bladder or cervix.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human KRT17 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

KRT17/8346R

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

46 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

39.1, CK 17, CK-17, Cytokeratin-17, K17, K1C17_HUMAN, Keratin, Keratin 17, keratin 17 epitope S1, keratin 17 epitope S2, keratin 17 epitope S4, Keratin 17, type I, Keratin type I cytoskeletal 17, keratin, type i cytoskeletal 17 [version 1], Keratin-17, KRT17, PC, PC2, PCHC1, type I cytoskeletal 17