Anti-Cytokeratin 17 Antibody [KRT17/4604] - BSA and Azide free (A278276)

Anti-Cytokeratin 17 Antibody [KRT17/4604] - BSA and Azide free

Mouse monoclonal [KRT17/4604] antibody to Cytokeratin 17.

Cytokeratin 17 (CK17) is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glandssuch as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. Additionally, anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human Cytokeratin 17.

Mouse

Monoclonal

KRT17/4604

IgG1

Protein A/G chromatography.

1 mg/ml

46 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Cytokeratin 17 Antibody [KRT17/4604] (A277688).

39.1, CK-17, Cytokeratin-17, K17, Keratin, type I cytoskeletal 17, Keratin-17, KRT17