Ricombinante Anti-Cytokeratin 15 Anticorpo [KRT15/8312R] (A314857)

Anti-Cytokeratin 15 Antibody [KRT15/8312R]

Recombinant rabbit monoclonal [KRT15/8312R] antibody to Cytokeratin 15.

Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. KRT15 is downregulated in activated keratinocytes. It is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

IHC-P

HeLa, A431 cells. Human skin or colon.

IHC: 1-2 µg/ml

Human

Recombinant human full-length KRT15 protein.

Rabbit

Monoclonal

KRT15/8312R

IgG

Unconjugated

Protein A chromatography.

200 µg/ml

52 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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