Ricombinante Anti-Cytokeratin 14 Anticorpo [KRT14/7054R] (A316240)

Anti-Cytokeratin 14 Antibody [KRT14/7054R] - BSA and Azide free

Recombinant rabbit monoclonal [KRT14/7054R] antibody to Cytokeratin 14.

Cytokeratin 14 is a member of the type I keratin family of intermediate filament proteins. It always pairs with the type II keratin K5 and form the primary keratin pair of the keratinocytes of stratified squamous epithelia, including the epidermis as well as mucosal non-keratinizing stratified squamous epithelia.Cytokeratin 14 is strongly expressed in the undifferentiated basal cell layer containing the stem cells and are down-regulated in the differentiating suprabasal cell layers. Otherwise, in the widely well stratified follicular outer root sheath, cytokeratin 14 is uniformly expressed throughout all layers. The expression spectrum of cytokeratin 14 in tumors corresponds well to the patterns in normal epithelia. Thus, most squamous cell carcinomas as well as malignant mesotheliomas strongly express this keratin whereas little, focal, or no expression is found in adenocarcinomas.Cytokeratin 14 may be a useful marker in the differential diagnosis of squamous cell carcinoma from other epithelial tumors. Recent studies also indicate that CK14 expression in breast cancer corresponded with poor clinical outcome and that CK14 may have diagnostic value in the sub-classification of NSCLC.

WB, IHC-P

A431 or HeLa cells. Human prostate, skin or squamous cell carcinoma.

WB: 1-2 µg/ml, IHC: 1-2 µg/ml

Human

Recombinant human KRT14 fragment (around Amino Acids 350-472). The exact sequence is proprietary.

Rabbit

Monoclonal

KRT14/7054R

kappa

Unconjugated

Protein A/G chromatography.

1 mg/ml

50 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CK 14, CK-14, ck14, Cytokeratin-14, Cytokeratin14, Dowling Meara, EBS3, EBS4, Epidermolysis bullosa simplex, K14, K1C14_HUMAN, Keratin, Keratin 14, Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner), Keratin type I cytoskeletal 14, Keratin, type I cytoskeletal 14, Keratin-14, Keratin14, Koebner, Krt 14, Krt14, NFJ, OTTHUMP00000164624, type I cytoskeletal 14