Ricombinante Anti-Cytokeratin 10 Anticorpo [rKRT10/6923] (A314837)

Anti-Cytokeratin 10 Antibody [rKRT10/6923]

Recombinant mouse monoclonal [rKRT10/6923] antibody to Cytokeratin 10.

This MAb recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more differentiated parts.

IHC-P

Human esophagus or tonsil.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 384-584) of human KRT10 protein. The exact sequence is proprietary.

Mouse

Monoclonal

rKRT10/6923

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

56.5 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

BCIE, BIE, CK 10, CK-10, Cytokeratin-10, EHK, K10, K1C10_HUMAN, Keratin, Keratin 10, Keratin 10 type I, Keratin type i cytoskeletal 10, Keratin type I cytoskeletal 59 kDa, Keratin-10, Keratin10, KPP, KRT10, type I cytoskeletal 10