Anti-CPS1 Anticorpo [SPM615] (A251438)

Anti-CPS1 Antibody [SPM615] - BSA and Azide free

Mouse monoclonal [SPM615] antibody to CPS1.

This antibody recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCCs occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

IF, IHC-P

IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human, Canine

Recombinant human CPS1 protein.

Mouse

Monoclonal

SPM615

IgG1

kappa

Protein A/G chromatography.

1 mg/ml

~165 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CPS1 Antibody [SPM615] (A248256).

Carbamoyl phosphate synthase, Carbamoyl phosphate synthase [ammonia], Carbamoyl phosphate synthase [ammonia] mitochondrial, Carbamoyl phosphate synthetase 1, Carbamoyl phosphate synthetase 1 mitochondrial, Carbamoyl phosphate synthetase I, Carbamoyl-phosphate synthase [ammonia], Carbamoyl-phosphate synthetase I, Carbamoylphosphate synthase, Carbamoylphosphate synthetase 1, Carbamoylphosphate synthetase I, CPS 1, CPSase 1, CPSase I, CPSASE1, CPSM_HUMAN, mitochondrial, MS738